L016 Pill – Bupropion 300mg for Depression, SAD & Smoking Cessation

L016 Pill (Bupropion XL 300mg) EXPLAINED: Uses, Dosage, Side Effects & Depression Relief Guide [2025]

⚠️ Medical Disclaimer: This article is for informational purposes only. Always consult a licensed healthcare professional before starting or stopping any medication.

What is the L016 Pill?

The L016 white pill is a prescription-only medication containing Bupropion Hydrochloride Extended-Release (XL) 300 mg. It’s commonly used for:

• Treating Major Depressive Disorder (MDD)

• Managing Seasonal Affective Disorder (SAD)

• Supporting smoking cessation (under the brand Zyban)

Imprint: L016
Color: White
Shape: Round
Size: ~9 mm
Drug Class: Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)
Formulation: Extended Release (XL)

How Bupropion Works

Unlike SSRIs (like sertraline), Bupropion does not affect serotonin. Instead, it works by increasing dopamine and norepinephrine levels in your brain. These two neurotransmitters are associated with:

• Motivation

• Pleasure

• Energy

• Mental focus

Bupropion is often preferred for people with fatigue-based depression or those sensitive to sexual side effects from SSRIs.

Common Medical Uses of the L016 Pill

Dosage & Timing Guidelines

Important:

• Always keep 24 hours between doses

• Take with food if it upsets your stomach

• Do not crush, chew, or split XL tablets

Serious Warning: Seizure Risk

L016 (Bupropion XL) carries a dose-dependent risk of seizures, especially if:

• You exceed 300 mg/day

• You drink alcohol heavily

• You have eating disorders (bulimia/anorexia)

• You take interacting meds (e.g., MAOIs, antipsychotics)

If you feel confused, lose consciousness, or twitch involuntarily, seek emergency help immediately.

Side Effects of L016 Pill (Bupropion XL 300mg)

Common (usually temporary):

• Insomnia

• Dry mouth

• Anxiety or restlessness

• Headaches

• Increased sweating

• Nausea

Less Common:

• Dizziness

• Fast heartbeat

• Irritability

• Shaky hands

Serious (rare):

• Seizures

• Hallucinations

• Suicidal thoughts (especially under 25)

• Blurred vision or eye pain

Most side effects fade within the first 2–4 weeks.

L016 and Sleep Disruption

Because Bupropion is activating, taking it at night may cause insomnia. Tips:

• Take it early in the morning (7–10am)

• Avoid caffeine late in the day

• Ask doctor if switching to SR (sustained release) is better

L016 vs Wellbutrin XL vs Zyban

Functionally the same – only branding and FDA labeling differs.

Expert Commentary

“Bupropion is unique among antidepressants. It boosts energy and has fewer sexual side effects, but seizure risk means we’re careful about who gets it and how it’s dosed.”
— Dr. E. Stone, Clinical Psychiatrist

L016 pill and Alcohol: A Risky Combo

Avoid alcohol while taking Bupropion. Even moderate drinking may increase:

• Seizure risk

• Mood instability

• Blood pressure

• Sleep problems

If you drink, be honest with your doctor.

L016 pill vs SSRIs and SNRIs

Real-Life Stories

“Within 3 weeks, I had more energy and stopped craving cigarettes.”
— Daniel, 34, ex-smoker

“I had vivid dreams and dry mouth at first, but my depression lifted.”
— Maya, 28, SAD patient

“I used to feel flat on SSRIs. L016 helped me feel alive again.”
— Jon, 41, recovering from burnout

L016 pill FAQ Section

❓ Can I take L016 at night?

❌ Not recommended. It may cause insomnia.

❓ How long until I feel results?

⏳ Most people feel improvement in 2–4 weeks, though energy may return earlier.

❓ Is it safe for teenagers?

⚠️ Use only if prescribed. Risk of suicidal thoughts is higher under age 25.

❓ What if I miss a dose?

⛔ Skip it. Do NOT double-dose Bupropion.

Pros and Cons of L016 Pill

Pros:

• Boosts motivation and energy

• Minimal sexual side effects

• Can help stop smoking

• Weight-neutral or weight-loss effect

• Affordable generic option

Cons:

• Risk of seizures if misused

• May cause anxiety early on

• Not suitable for patients with eating disorders

• Can’t be mixed with alcohol

Dofollow Authority Links

1. Bupropion: Uses, Dosage, Side Effects – Drugs.com
   

2. Bupropion (oral route) – Mayo Clinic

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