M367 Pill – Hydrocodone 10mg + Acetaminophen for Severe Pain Relief (2025)
⚠️ Disclaimer: This article is for educational purposes only. Always consult a healthcare provider before starting or adjusting any prescribed medication.
What Is the M367 Pill?
The M367 pill is a white, capsule-shaped prescription tablet imprinted with “M367.” It contains:
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Hydrocodone Bitartrate (10 mg) – a semi-synthetic opioid that relieves moderate to severe pain by affecting the brain’s pain receptors.
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Acetaminophen (325 mg) – a non-opioid analgesic that reduces pain and fever.
Together, they form a powerful pain relief combination, often prescribed for post-surgical recovery, trauma-related pain, or chronic pain when other medications fail.
Pill Identification Overview
| Feature | Description |
|---|---|
| Imprint | M367 |
| Shape | Capsule / Oblong |
| Color | White |
| Strength | 10 mg Hydrocodone + 325 mg Acetaminophen |
| Drug Class | Opioid Analgesic + Non-Opioid |
| Legal Status | Schedule II (Controlled Substance) |
| Availability | Prescription Only |
| Manufacturer | Mallinckrodt Pharmaceuticals |
What Is the M367 Pill Used For?
M367 is prescribed for moderate to severe pain. It’s often used in cases like:
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Post-surgical recovery (e.g., after dental, orthopedic, or abdominal surgery)
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Trauma-related pain (e.g., fractures, sprains)
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Cancer pain (often in combination with other medications)
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Chronic pain conditions (e.g., back pain, arthritis, nerve pain)
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Severe headaches or migraines (if other options fail)
M367 does not reduce inflammation, so it’s not ideal for conditions like arthritis or sports injuries that involve swelling.
How Long Does M367 Take to Work?
| Stage | Timeframe |
|---|---|
| Onset | 30–60 minutes (typically) |
| Peak Effect | 1–2 hours |
| Duration | 4–6 hours (depends on dosage) |
| Elimination | 12–24 hours (for full hydrocodone trace elimination) |
✅ M367 is fast-acting, with most patients experiencing relief within 30 minutes. However, its effects can last up to 6 hours, providing significant coverage for daily pain management.
M367 vs Other Opioids (Norco, Vicodin, M365)
| Feature | M367 | Norco | Vicodin | M365 |
|---|---|---|---|---|
| Hydrocodone Dose | 10 mg | 5–10 mg | 5 mg | 10 mg |
| Acetaminophen Dose | 325 mg | 325 mg | 300 mg | 325 mg |
| Onset | 30–60 minutes | 30–60 minutes | 30–60 minutes | 30 minutes |
| Duration | 4–6 hours | 4–6 hours | 4–6 hours | 4–6 hours |
| Use | Moderate to severe pain | Moderate pain relief | Moderate pain relief | Severe pain (higher dose) |
| Addiction Risk | High (due to hydrocodone) | Moderate-High | Moderate-High | High (due to hydrocodone) |
Real-Life Use Cases for M367 Pill
Case 1: Post-Surgical Pain Relief
Sarah (age 35) was prescribed M367 after a gallbladder surgery. She took 1 pill every 4–6 hours for 4 days, then tapered down to Tylenol for ongoing recovery.
Case 2: Trauma Recovery
Keith (age 52) suffered a severe leg fracture from a fall. His doctor recommended M367 for the first 5 days to manage acute pain, then transitioned to a lower-dose prescription.
Case 3: Cancer Pain Management
Elaine (age 60) has advanced bone cancer. Her oncologist prescribed M367 for breakthrough pain as part of her pain management regimen, along with a long-acting opioid.
Case 4: Chronic Back Pain
Robert (age 48) uses M367 for chronic back pain, under strict doctor supervision, alternating between M367 and NSAIDs for daily pain management.
Case 5: Post-Accident Pain
Vanessa (age 40) was in a car accident and needed M367 for initial pain relief. She used the medication for 3 days and was advised to gradually reduce usage with her physician’s help.
M367 Dosage and Safety Guide
| Patient Group | Dose | Frequency | Max per Day |
|---|---|---|---|
| Adults (18+) | 1 tablet (10 mg hydrocodone) | Every 4–6 hours | Max: 8 tablets (4000 mg acetaminophen) |
| Elderly (65+) | Start with ½ tablet | Every 6–8 hours | Max: 4 tablets (consult doctor) |
| Children <12 | ❌ Not recommended | — | — |
⚠️ Hydrocodone overdose can lead to fatal respiratory depression, especially when taken with other sedatives or alcohol.
Opioid Safety: Risks of M367 pill
Potential for Addiction & Abuse
Hydrocodone is a Schedule II controlled substance. Long-term use or misuse can result in physical dependence and addiction. It’s crucial to use M367 only under strict medical supervision, especially for those with a history of substance use disorder.
⚠️ Side Effects:
| Common Effects | Severity |
|---|---|
| Drowsiness | Moderate |
| Constipation | Mild |
| Dizziness | Moderate |
| Nausea | Mild |
| Severe Effects | |
| Respiratory depression | Severe |
| Confusion, delirium | High |
| Liver toxicity | Severe |
⚠️ Overdose warning: Always ensure dosage safety, especially when combining with alcohol or benzodiazepines.
Expert Opinions
“The combination of hydrocodone and acetaminophen in M367 provides effective relief for severe pain, but the hydrocodone content increases the risk of dependency and overdose.”
— Dr. Lisa Hammond, Pain Management Specialist
“Patients often misuse these pills for their sedative effect. It’s important to educate people on the dangers of opioid pain relief.”
— Dr. Marcus Reed, Addiction Medicine Expert
“M367 should be used only as a last resort for chronic pain management. Other alternatives should be explored to minimize the risk of addiction.”
— Dr. Emily Carlson, Family Medicine Physician
Pros and Cons of M367 Pill
Pros
| Benefit |
|---|
| Effective for moderate to severe pain |
| Provides extended relief (4–6 hrs) |
| Acetaminophen boosts pain relief without additional sedation |
| Cost-effective compared to brand-name opioids |
| Often preferred for post-surgical or trauma-related pain |
Cons
| Risk |
|---|
| High risk of addiction (hydrocodone component) |
| Respiratory depression in overdose |
| Liver damage from acetaminophen overdose |
| Drowsiness and impaired motor skills |
| Not suitable for long-term use without monitoring |
| Misuse potential (in combination with other CNS depressants) |
FAQ – M367 Pill
❓ How does M367 compare to other opioids like Norco or Vicodin?
✅ M367 contains 10 mg of hydrocodone compared to 5 mg in Norco. This gives it a stronger effect, but also increases risk of side effects.
Can I take M367 with alcohol?
❌ Never combine M367 with alcohol or other sedatives. This increases the risk of overdose, respiratory depression, and death.
Can I use M367 for long-term pain relief?
⚠️ No. M367 is not recommended for long-term use. Chronic use can result in dependence and tolerance.
What should I do if I miss a dose of M367?
✅ Take the dose as soon as you remember, but never double dose. If it’s almost time for the next dose, skip the missed dose.
Can I give M367 pill to my dog?
⚠️ No, M367 contains hydrocodone, which is toxic to dogs. Always consult a vet for pet pain relief.
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Final Takeaway
The M367 pill is a strong opioid pain reliever and should only be used under strict medical supervision. While it offers effective pain relief, the high potential for addiction and liver damage means it should be used only for severe pain and for the shortest duration possible.
Important: Do not mix with alcohol or other sedatives. Consult your doctor if you have a history of substance use disorder or liver disease.
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